产品货号：
Z35734
中文名称：
NTN1抗体
英文名称：
Anti-NTN1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NTN1 Antibody |
| 指标别名 | netrin 1;NTN1;NTN1L;NTN1-Specific |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | NTN1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human Netrin 1 |
| 实际分子量 | 75KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Netrin-1(NTN1),also known as NTN1L,is a diffusible protein made by floor plate cells.Netrin-1 is found in the floor plate and neuroepithelial cells of the ventral region of the spinal cord,as well as other locations in the nervous system including the somatic mesoderm,pancreas and cardiac muscle.The human NTN1 gene is mapped to chromosome 17p13-p12 by FISH.Netrin-1 can attract spinal commissural axons and repel trochlear axons in vitro.And netrin-1 expression confers a selective advantage for tumor cell survival.The binding of netrin-1 to DCC appears to depend on the presence of a coreceptor or accessory proteins.Adenosine A2b receptor is actually a netrin-1 receptor and induces cAMP accumulation on binding netrin-1,and that netrin-1-dependent outgrowth of dorsal spinal cord axons directly involves A2b.Netrin-1 can promote intestinal tumor development,probably by regulating cell survival.Thus,a netrin-1 receptor or receptors function as conditional tumor suppressors.Expression of Unc5b triggered endothelial cell repulsion in response to netrin-1 in vitro,whereas a truncated Unc5b lacking the intracellular signaling domain failed to induce repulsion. |
| Uniprot ID | O95631 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
相关搜索：NTN1抗体，NTN1单抗，Anti-NTN1 Antibody